Targeting Enzymes for Pharmaceutical Development
portes grátis
Targeting Enzymes for Pharmaceutical Development
Methods and Protocols
Labrou, Nikolaos
Springer-Verlag New York Inc.
12/2019
310
Dura
Inglês
9781071601624
Pré-lançamento - envio 15 a 20 dias após a sua edição
This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals.
1. In Silico Laboratory: Tools for Similarity-Based Drug Discovery Samo Lesnik and Janez Konc 2. The In Silico Fischer Lock-and-Key Model: The Combined Use of Molecular Descriptors and Docking Poses for the Repurposing of Old Drugs Marco Tutone and Anna Maria Almerico 3. Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor Nikolaos Georgakis, Elisavet Ioannou, Christina Varotsou, Geogios Permetis, Evangelia G. Chronopoulou, and Nikolaos E. Labrou 4. Applications of Differential Scanning Fluorometry and Related Technologies in Characterization of Protein-Ligand Interactions Bolormaa Baljinnyam, Michael Ronzetti, Adam Yasgar, and Anton Simeonov 5. High-Throughput Differential Scanning Fluorimetry of GFP-Tagged Proteins Alanna E. Sorenson and Patrick M. Schaeffer 6. Enzyme-Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism Rohanah Hussain, Charlotte S Hughes, and Giuliano Siligardi 7. Measuring Small Molecule Binding to Escherichia coli AcrB by Surface Plasmon Resonance Steven W. Polyak, Rumana Mowla, and Henrietta Venter 8. Systematic Screening of Viral Entry Inhibitors Using Surface Plasmon Resonance Penmetcha K.R. Kumar 9. Screening of Beta-Secretase Inhibitors by Capillary Electrophoresis-Mass Spectrometry Jan Schejbal, Roman Reminek, and Zdenek Glatz 10. Electrophoretic Mobility Shift Assays with GFP-Tagged Proteins (GFP-EMSA) Alanna E. Sorenson and Patrick M. Schaeffer 11. On-Line Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors Roman Reminek, Zdenek Glatz, and Wolfgang Thormann 12. Enzymatic Bioautographic Methods I. Ayelen Ramallo, Mario O. Salazar, and Ricardo L.E. Furlan 13. High-Throughput Assessment of Metabolism-Induced Toxicity of Compounds on a 384-Pillar Plate Soo-Yeon Kang, Kyeong-Nam Yu, Pranav Joshi, and Moo-Yeal Lee 14. Droplet-Based Microfluidics Methods for Detecting Enzyme Inhibitors Abraham Ochoa, Frida Trejo, and Luis F. Olguin 15. Ligand Fishing: An Approach for the Discovery Inhibitors from Complex Biological Mixtures Evangelia G. Chronopoulou, Christina Varotsou, Nikolaos Georgakis, Georgios Permetis, Elisavet Ioannou, and Nikolaos E. Labrou 16. HMG-CoA Reductase as Target for Drug Development Baskaran Gunasekaran and Mohd Yunus Shukor 17. Lipoxygenases as Targets for Drug Development Xiao-Yuan Mao 18. Cholinesterase as a Target for Drug Development in Alzheimer's Disease Piyoosh Sharma, Manish Kumar Tripathi, and Sushant Kumar Shrivastava
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This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals.
1. In Silico Laboratory: Tools for Similarity-Based Drug Discovery Samo Lesnik and Janez Konc 2. The In Silico Fischer Lock-and-Key Model: The Combined Use of Molecular Descriptors and Docking Poses for the Repurposing of Old Drugs Marco Tutone and Anna Maria Almerico 3. Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor Nikolaos Georgakis, Elisavet Ioannou, Christina Varotsou, Geogios Permetis, Evangelia G. Chronopoulou, and Nikolaos E. Labrou 4. Applications of Differential Scanning Fluorometry and Related Technologies in Characterization of Protein-Ligand Interactions Bolormaa Baljinnyam, Michael Ronzetti, Adam Yasgar, and Anton Simeonov 5. High-Throughput Differential Scanning Fluorimetry of GFP-Tagged Proteins Alanna E. Sorenson and Patrick M. Schaeffer 6. Enzyme-Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism Rohanah Hussain, Charlotte S Hughes, and Giuliano Siligardi 7. Measuring Small Molecule Binding to Escherichia coli AcrB by Surface Plasmon Resonance Steven W. Polyak, Rumana Mowla, and Henrietta Venter 8. Systematic Screening of Viral Entry Inhibitors Using Surface Plasmon Resonance Penmetcha K.R. Kumar 9. Screening of Beta-Secretase Inhibitors by Capillary Electrophoresis-Mass Spectrometry Jan Schejbal, Roman Reminek, and Zdenek Glatz 10. Electrophoretic Mobility Shift Assays with GFP-Tagged Proteins (GFP-EMSA) Alanna E. Sorenson and Patrick M. Schaeffer 11. On-Line Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors Roman Reminek, Zdenek Glatz, and Wolfgang Thormann 12. Enzymatic Bioautographic Methods I. Ayelen Ramallo, Mario O. Salazar, and Ricardo L.E. Furlan 13. High-Throughput Assessment of Metabolism-Induced Toxicity of Compounds on a 384-Pillar Plate Soo-Yeon Kang, Kyeong-Nam Yu, Pranav Joshi, and Moo-Yeal Lee 14. Droplet-Based Microfluidics Methods for Detecting Enzyme Inhibitors Abraham Ochoa, Frida Trejo, and Luis F. Olguin 15. Ligand Fishing: An Approach for the Discovery Inhibitors from Complex Biological Mixtures Evangelia G. Chronopoulou, Christina Varotsou, Nikolaos Georgakis, Georgios Permetis, Elisavet Ioannou, and Nikolaos E. Labrou 16. HMG-CoA Reductase as Target for Drug Development Baskaran Gunasekaran and Mohd Yunus Shukor 17. Lipoxygenases as Targets for Drug Development Xiao-Yuan Mao 18. Cholinesterase as a Target for Drug Development in Alzheimer's Disease Piyoosh Sharma, Manish Kumar Tripathi, and Sushant Kumar Shrivastava
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
